Top 7 Weight Loss Supplements in the U.S. (2025)

Written By

Pleasure in Health

Looking for the best weight loss supplements in 2025? Discover the top 7 fat burners and natural appetite suppressants trusted by thousands in the U.S. to boost metabolism and burn stubborn fat.

PhenQ – Best Overall Formula

Written By

Pleasure in Health

PhenQ combines five fat-loss mechanisms in one product: it burns fat, blocks new fat production, suppresses appetite, boosts energy, and improves mood. It's made with clinically studied ingredients and is suitable for vegans. Its main compounds like α-Lacys Reset® and Capsimax are known for supporting effective and lasting fat loss in both men and women.

LeanBean is a weight loss supplement designed specifically for women. Its powerful blend includes glucomannan, a natural fiber that helps reduce cravings and calorie intake. The formula is stimulant-light, making it ideal for those sensitive to caffeine. It supports hormonal balance and metabolism, especially during menstruation, menopause, or high-stress periods.

LeanBean – Best for Women

PrimeShred targets body fat while preserving lean muscle, which makes it a favorite among those in cutting phases or who follow fitness routines. It contains ingredients like cayenne pepper and L-theanine that not only promote thermogenesis but also enhance energy, focus, and mental clarity—key elements during intense training or fat-loss periods.

PrimeShred – Best for Muscle Definition

HepatoBurn is a dual-action supplement that helps burn fat by supporting liver function and optimizing mitochondrial energy. It features ingredients like artichoke extract, dandelion root, and other compounds that promote detoxification and fat metabolism. It’s ideal for people with slow metabolism due to poor liver health or hormonal imbalances.

HepatoBurn – Best for Liver-Driven Fat Loss

Mitolyn works at the cellular level by enhancing mitochondrial function, allowing the body to convert stored fat into clean, usable energy more efficiently. With key ingredients like PQQ, CoQ10, and acetyl-L-carnitine, it is especially effective for individuals over 35 or those who experience chronic fatigue, metabolic slowdown, or stubborn weight retention.

Mitolyn – Best for Cellular Fat Burning

Java Burn is a tasteless powder you mix into your morning coffee, designed to boost metabolism and enhance fat burning without altering your routine. Its blend of green tea extract, L-theanine, and chromium synergizes with caffeine to accelerate thermogenesis, suppress appetite, and balance blood sugar levels. Ideal for coffee lovers looking for a discreet fat burner.

Java Burn – Best Coffee-Compatible Fat Burner

Zotrim is a herbal supplement known for clinically proven appetite control. It contains yerba mate, guarana, and damiana leaf, which work together to reduce hunger, improve satiety, and promote weight management. Unlike many fat burners, Zotrim is caffeine-light and well tolerated, making it a solid choice for consistent use without side effects.

Zotrim – Best Natural Appetite Suppressant